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How Long Does Tramadol Stay in Your System?

How Long Does Tramadol Stay in Your System?

Tramadol is an effective prescription opioid medicine used to treat modest to severe pain and is sold in the market and online under the brands Conzip and Ultram. It is often prescribed by doctors for treatment of pain after surgery. The medication may also be administered for chronic pain which is caused by conditions like neuropathy or cancer. However, this drug can be habit-forming if used for a long duration of time without the approval of a physician.

How Long Does It Take to Experience Tramadol Effects?

The medicine works on opioid pain receptors present in the brain and all over central nervous system. Tramadol also weakly curbs the reuptake of neurotransmitters: norepinephrine and serotonin. After taking a dose, the relief effects begin usually after an hour and peaks in 2 to 4 hours. Moreover, there are extended relief versions that dispense doses in phases over a long time. This entails that a single extended tablet works longer in the system.

While it is active, the medication depresses breathing process and causes pupils to compress. Tramadol reduces mobility in the digestive system;therefore, food takes a bit longer to digest, which in turn, forces a person to experience constipation. The drug dilates the blood vessels, which can force an individual to experience sweating, itching, flushing, red eyes, faintness or dizziness when they get up after lying down.

How Long Tramadol Remains in the Human Body?

The discharge of Tramadol starts in the liver where, as an effect of specific enzymatic processes, twenty-three metabolites are created. The major metabolites are N-desmethyl-tramadol, and O-desmethyl-tramadol that is pharmacologically active. The metabolites are primarily eliminated through the kidneys. The medicine has half-life of 4-5 hours and O-desmethyl-tramadol has longer half-life of 7-8 hours. A medication’s half-life shows the time it takes for an individual to get rid of half of the serum of consumed substance.

Though, the medication is not detected on all the regular drug tests, it could be detected on some sophisticated or advanced screening panels. Blood tests, saliva tests, hair tests and urine tests are the common types of drug tests.

  • A urine test can find tramadol traces from one to four days after last use.
  • A hair test has a detection window of four to six months after last use. Nonetheless, one research found traces in an individual’s hair at seven months.
  • Saliva tests have short detection window of 48 hours after last use.
  • A blood test can be taken to find traces of tramadol, though it only provides a detection window of around 12 to 24 hours after last use.

Individual factors like hydration, metabolism, weight and age all impact the overall results of drug test. Furthermore, the dosage taken and the duration taking tramadol would impact how long traces of this medication can be detected in human body.

On the other hand, a lot of other factors could affect how long tramadol remains in the body. These include:

  • How much you consumed the dose? The higher the dosage, the longer the drug will stay in body.
  • Generally, a single dose would remain in the body for short time. If you take tramadol doses regularly, they will stay in the system for a long period of time.
  • Tramadol injections or drops are absorbed and discharged from the body faster than pills.
  • Metabolism pertains to chemical process of breaking up substances you ingest like medication or food. The metabolic rate could be affected by many factors, including genetics, body composition, diet, age and activity level. Having slow metabolism might increase the time it would take to break down tramadol.
  • Reduced liver or kidney function can increase the time it takes for the human body to eliminate tramadol.
  • If you are above the age of 75, your body will take more time to eliminate tramadol.

Although, tramadol is a useful medication to treat different types of pain, it can cause side effects, withdrawal symptoms, addiction and dependence if it is not used under the supervision of a doctor. In order to avoid unwanted effects and recuperate properly from your disease or pain, you should always take the doses of tramadol as told by your healthcare practitioner.


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